aminolevulinic acid การใช้

• Delta-aminolevulinate synthase catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid.
• One of the treatments is using blue light with aminolevulinic acid for the treatment of actinic keratosis.
• ALAS2 is an aminolevulinic acid synthase.
• ALAS1 is an aminolevulinic acid synthase.
• It is isomerized by glutamate-1-semialdehyde 2, 1-aminomutase to give aminolevulinic acid in the biosynthesis of porphyrins, including heme and chlorophyll.
• "' Delta-aminolevulinic acid dehydratase "'is found in blood and is involved in the production of the heme group of globins.
• X-linked sideroblastic anemia or " X-linked dominant erythropoietic protoporphyria ", associated with ALAS2 ( aminolevulinic acid synthase ), has also been described.
• Pyridoxal phosphate ( a derivative of pyridoxine ) is required for d-aminolevulinic acid synthase, the enzyme responsible for the rate-limiting step in heme synthesis.
• "' Porphobilinogen synthase "'( or "'ALA dehydratase "', or "'aminolevulinate dehydratase "') synthesizes porphobilinogen through the asymmetric condensation of two molecules of aminolevulinic acid.
• The chances of near-complete initial removal of the tumor may be increased if the surgery is guided by a fluorescent dye known as 5-aminolevulinic acid.
• Screening for " FECH " mutation on one allele or aminolevulinic acid synthase 2 gain-of-function mutation in selected family members may be useful, especially in genetic counseling.
• For example, iron is used in the active site of glutamyl-tRNA reductase, an enzyme needed for the formation of 5-Aminolevulinic acid which is a precursor of heme and chlorophyll.
• Additionally, alcohol has been shown to increase the activity of the delta-aminolevulinic acid synthetase ( ALA synthetase ), the rate-limiting enzymatic step in heme synthesis in the mitochondria, in rats.
• It is given intravenously, and its action of mechanism is to reduce the overproduction of ?-aminolevulinic acid, which can cause the acute symptoms in an attack of the acute porphyrias.
• The pathway is initiated by the synthesis of D-aminolevulinic acid ( dALA or ?ALA ) from the amino acid glycine and succinyl-CoA from the citric acid cycle ( Krebs cycle ).
• In another study, Anderson got similar results with a different laser, plus a cream containing ALA ( aminolevulinic acid ), a natural substance that makes cells, including hair cells, sensitive to light.
• "' ?-Aminolevulinic acid "'( dALA or ?-ALA or 5ala or 5-aminolevulinic acid ) is the first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals and chlorophyll in plants.
• "' ?-Aminolevulinic acid "'( dALA or ?-ALA or 5ala or 5-aminolevulinic acid ) is the first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals and chlorophyll in plants.